Tag: Gabapentin

How Many Health Conditions Can Gabapentin Treat ?

Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain.Gabapentin is used in adults to treat nerve pain caused by herpes virus or shingles (herpes zoster).

The Horizant brand of gabapentin is also used to treat restless legs syndrome (RLS).The Neurontin brand of gabapentin is also used to treatseizures in adults and children who are at least 3 years old.

Gabapentin is also be used to treat following health conditions:

  • Alcohol Withdrawal
  • Anxiety
  • Benign Essential Tremor
  • Bipolar Disorder
  • Burning Mouth Syndrome
  • Cluster-Tic Syndrome
  • Cough
  • Diabetic Peripheral Neuropathy
  • Epilepsy
  • Erythromelalgia
  • Fibromyalgia
  • Hiccups
  • Hot Flashes
  • Hyperhidrosis
  • Insomnia
  • Lhermitte’s Sign
  • Migraine
  • Nausea/Vomiting, Chemotherapy Induced
  • Neuropathic Pain
  • Occipital Neuralgia
  • Pain
  • Periodic Limb Movement Disorder
  • Peripheral Neuropathy
  • Postherpetic Neuralgia
  • Postmenopausal Symptoms
  • Pruritus
  • Pudendal Neuralgia
  • Reflex Sympathetic Dystrophy Syndrome
  • Restless Legs Syndrome
  • Small Fiber Neuropathy
  • Spondylolisthesis
  • Syringomyelia
  • Transverse Myelitis
  • Trigeminal Neuralgia
  • Vulvodynia

Gabapentin is a medication primarily used to treat epilepsy (seizure disorders) and neuropathic pain (pain caused by nerve damage). However, it has also been prescribed for several other health conditions off-label, meaning its use for these conditions is not FDA-approved but may be prescribed by healthcare providers based on clinical judgment and evidence.

Some of the health conditions for which gabapentin may be prescribed off-label include:

    1. Chronic pain conditions such as fibromyalgia
    2. Postherpetic neuralgia (nerve pain following shingles)
    3. Restless legs syndrome (RLS)
    4. Migraine prevention
    5. Hot flashes associated with menopause
    6. Anxiety disorders, particularly generalized anxiety disorder (GAD)
    7. Bipolar disorder (as an adjunctive treatment)
    8. Insomnia
    9. Alcohol withdrawal symptoms
    10. Pruritus (itching) associated with various conditions

It’s important to note that while gabapentin may be effective for some of these conditions, its off-label use should be carefully considered by healthcare providers, and the risks and benefits should be discussed with the patient. Additionally, individual responses to gabapentin can vary, and not everyone may experience the same level of benefit or may experience side effects.

What Are the Best Medicines for Migraines?

Migraines are a type of headache disorder characterized by recurrent episodes of moderate to severe head pain, often accompanied by other symptoms such as nausea, vomiting, sensitivity to light, sound, or smells, and visual disturbances. Migraines can significantly impact daily life, leading to missed work or school days and reduced quality of life for those affected.

Here are some key characteristics of migraines:

  1. Pain: Migraine pain is often described as throbbing or pulsating and typically affects one side of the head, although it can also be bilateral. The pain can vary in intensity and may worsen with physical activity.
  2. Duration: Migraine attacks can last anywhere from a few hours to several days. Some individuals may experience a prodrome phase, which consists of subtle changes in mood, energy levels, or appetite, preceding the onset of a migraine attack.
  3. Associated Symptoms: In addition to head pain, migraines often involve other symptoms, such as nausea, vomiting, and sensitivity to light (photophobia) or sound (phonophobia). Some people may also experience visual disturbances, known as aura, which can include flashing lights, blind spots, or zigzag lines in their field of vision.
  4. Triggers: Migraine triggers vary widely among individuals but may include hormonal changes, certain foods or beverages (such as aged cheeses, chocolate, or alcohol), stress, lack of sleep, sensory stimuli (bright lights, loud noises), weather changes, and hormonal fluctuations.
  5. Types of Migraines: There are several subtypes of migraines, including migraine with aura (where individuals experience visual or sensory disturbances before the onset of pain), migraine without aura, hemiplegic migraine (accompanied by temporary paralysis or weakness on one side of the body), and vestibular migraine (associated with vertigo or dizziness).
  6. Impact on Daily Life: Migraines can significantly impact daily functioning, leading to missed work or school days, decreased productivity, and impaired quality of life. Managing migraines often requires a combination of medication, lifestyle modifications, and avoidance of triggers.

While the exact cause of migraines is not fully understood, they are believed to involve a complex interplay of genetic, environmental, and neurochemical factors. Migraines can occur at any age but often begin during adolescence or early adulthood and tend to affect women more frequently than men.

Treatment for migraines typically focuses on relieving symptoms during an attack (acute treatment) and preventing future attacks (preventive treatment) through medication, lifestyle modifications, and stress management techniques. It’s essential for individuals experiencing migraines to work closely with healthcare providers to develop a personalized treatment plan tailored to their needs and preferences.

What Are the Best Medicines for Migraines?

The best medicines for migraines can vary from person to person, as treatment often depends on the frequency, severity, and specific symptoms experienced. However, several medications are commonly used to prevent migraines or relieve symptoms when they occur. Here are some of the most commonly prescribed medications for migraines:

  1. Triptans: Triptans are a class of medications specifically designed to treat migraines. They work by narrowing blood vessels in the brain and blocking pain pathways. Examples include sumatriptan (Imitrex), rizatriptan (Maxalt), and eletriptan (Relpax). Triptans are typically most effective when taken at the onset of a migraine attack.
  2. NSAIDs (Nonsteroidal Anti-Inflammatory Drugs): NSAIDs such as ibuprofen (Advil, Motrin), naproxen (Aleve), and aspirin can help relieve migraine pain and inflammation when taken early in an attack. They are often used as a first-line treatment for mild to moderate migraines.
  3. Acetaminophen: Acetaminophen (Tylenol) may be used alone or in combination with other medications to relieve migraine pain. It’s often preferred for individuals who cannot take NSAIDs due to stomach issues or other contraindications.
  4. Ergotamines: Ergotamines, such as dihydroergotamine (D.H.E. 45) and ergotamine with caffeine (Migergot), are older medications that can be effective for treating migraines, particularly when triptans are not effective or tolerated. However, they are less commonly prescribed due to potential side effects and drug interactions.
  5. Calcium Channel Blockers: Medications such as verapamil and flunarizine, which are calcium channel blockers, may be prescribed to prevent migraines in some individuals, particularly those with frequent or severe attacks.
  6. Beta-Blockers: Certain beta-blockers, such as propranolol and metoprolol, are commonly used as preventive medications for migraines, especially in individuals with high blood pressure or other cardiovascular conditions.
  7. Anticonvulsants: Some anticonvulsant medications, such as topiramate (Topamax) and valproate (Depakote), may be prescribed to prevent migraines, particularly in individuals who also experience seizures or have not responded well to other preventive treatments.
  8. CGRP Inhibitors: Calcitonin gene-related peptide (CGRP) inhibitors, such as erenumab (Aimovig), fremanezumab (Ajovy), and galcanezumab (Emgality), are a newer class of medications specifically developed for migraine prevention. They work by targeting CGRP, a neurotransmitter involved in migraine attacks.

Best answer:

Answer by Kara
My sister has the disease, Daily Chronic Migraines. She’s been on everything from vitamins to sedatives and anti-histamines. Talk to a nuerologist near you, he’ll have you track all your symptoms, your migraines, what you were doing, when you ate around the time, etc etc. Trust me, you can get A LOT of help from doctors, rather than people here.

What do you think? Answer below!

Who Can not Buy Gabapentin Online ?

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You can not buy our Gabapentin online if:

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    • Asking a charge-back before.
    • You have sent checks not money orders to postman to cheat to get our package ;
    • Your doctor has sent us a letter not sending orders;
    • You have drug abuse history.

You can not buy gabapentin online if you have following health conditions:

    • 1. kidney disease;
      2. liver disease;
      3. heart disease; or
      4. (for patients with RLS) if you are a day sleeper or work a night shift.
      5. being pregnant;
      6. breast-feeding a baby;
      7. Having suicide thoughts.
      8. respiratory diseases

It does not mean you cannot take Gabapentin. If you have above health conditions, you must go to your local street doctor and let the doctor have your health checked.

Who Can Not Take Gabapentin Online ?

While gabapentin is generally considered safe for many people, there are certain individuals who should avoid taking it or use it with caution. Here are some groups of people who may need to avoid gabapentin or consult their healthcare provider before taking it:

  1. Allergic Reactions: If you have had an allergic reaction to gabapentin or any of its ingredients in the past, you should not take gabapentin.
  2. Kidney Problems: Gabapentin is primarily eliminated from the body through the kidneys. Individuals with impaired kidney function may require dosage adjustments or should avoid gabapentin altogether.
  3. Pregnant or Breastfeeding Women: The safety of gabapentin during pregnancy and breastfeeding is not well established. Pregnant or breastfeeding women should consult their healthcare provider before taking gabapentin to weigh the potential risks and benefits.
  4. Elderly Individuals: Older adults may be more sensitive to the side effects of gabapentin, such as dizziness and drowsiness. Dosage adjustments may be necessary for this population.
  5. History of Substance Abuse: Individuals with a history of substance abuse or addiction may be at a higher risk of misusing or abusing gabapentin, especially since it can cause feelings of relaxation or euphoria in some people.
  6. Mental Health Conditions: People with certain mental health conditions, such as depression or suicidal thoughts, should use gabapentin with caution and under close supervision, as it may increase the risk of suicidal thoughts or behavior.
  7. Other Medical Conditions: People with certain medical conditions, such as respiratory problems or myasthenia gravis, may need to avoid gabapentin or use it with caution due to potential interactions or exacerbation of symptoms.
  8. Interactions with Other Medications: Gabapentin can interact with certain medications, including opioids and other central nervous system depressants, which can increase the risk of respiratory depression and other adverse effects. It’s essential to inform your healthcare provider about all medications you are taking before starting gabapentin.

Gabapentin is an Addiction Treatment Medication

Gabapentin is used to treat cases of addiction in an off-label manner. Different companies, including Parke-Davis, Greenstone, and Teva, manufacture several varieties of the generic drug. Other drugs that have been used to treat the symptoms of addiction withdrawal, for specific substances, include:

      • Clondine
      • Other anticonvulsants, such as Tegretol and Depakote
      • Methadone and buprenorphine
      • Naltrexone

Typical Application

Available in capsules, tablets, and as an oral liquid, dosages range from 100 mg to 800 mg. The frequency with which a dose is repeated depends on the specific dose, which is usually based on the severity of withdrawal and the client’s weight. The drug’s half-life is around 5-7 hours.

Generally, it is used during medical detox and throughout subsequent treatment modalities to support relapse prevention while clients adjust to their new sober lifestyles.

Treating Substance Abuse

According to Medscape, gabapentin can inflict users with suicidal thoughts and abrupt changes in behavior. For this reason, it should only be used under medical supervision. It can also cause elevated blood pressure, fever, sleep problems, appetite changes, and chest pain.

While it has been used to treat addictions to other substances, gabapentin is most often used to treat alcoholism — an addiction some 16.6 million adults suffered from in 2013, per the National Institute on Alcohol Abuse and Alcoholism.

During withdrawal from alcohol abuse or dependency, clients may experience anxiety, tremors, agitation, and irritability. In order to understand how gabapentin works, there must be a basic understanding of how the brain works first. Nervous system activity is partially controlled by GABA neurotransmitters. Gabapentin works by reducing activity among GABA. As a result, signals for pain, agitation, and anxiety are reduced, too.

An American Journal of Psychiatry study showed impressive results during the 16-week treatment of 150 people who were dependent on alcohol, noting better results among those who were treated with both gabapentin and naltrexone than the latter alone. TheJournal of Clinical Psychiatry reported on another study in which individuals treated for alcoholism with gabapentin showed a significant reduction in how much they drank and a greater rate of abstinence than those in the placebo group.

Gabapentin has the same calming effect on individuals who are detoxing from marijuana and benzodiazepines. Despite claims from fans of the plant-based drug, marijuana is indeed addictive. In 2012, 305,560 people checked into rehab citing cannabis as their primary drug of abuse, per the Substance Abuse and Mental Health Services Administration. One Neuropsychopharmacology study that analyzed the use of gabapentin in the treatment of marijuana addiction and withdrawal noted individuals in the gabapentin treatment group used less marijuana, had fewer withdrawal symptoms, and experienced improvements in cognitive functioning, compared to the placebo group.

Gabapentin is Also Used to Treat Alcohol Withdrawal

I am still on gabapentin. Dose is 600mg three times a day – total 1800mg in a 24 hour period. I had not had a drink “craving” since August 11, 2014 when I quit. (I did this within one week of starting gabapentin).

I did have a glass of wine at Christmas, one beer on my birthday, and one glass of wine at Easter. That’s it. I use to have 10 beers a day, and three glasses of wine or gin for bad panic attacks and generalized anxiety. So for me (not everyone) I can have that occasional drink with friends, at party or any social event – then come home and not touch the stuff and WITHOUT ANY CRAVINGS AT ALL – as I had during my 40-year binge. Still, this drug is amazing. AA never worked for me.

“I went on gabapentin for alcoholism that troubled me for 10 years when nothing including Alcoholics Anonymous barely worked. I read anecdotal information that it helped with alcoholism, went on 600mg twice daily and it was the first thing that helped me.

Now I take 1200mg twice daily and find it works great! Afterwards I read a study in the Journal of American Medicine, Gabapentin in Alcohol Dependance, 2014 that confirmed it works well in many people for cravings and binge drinking. This medicine should be further studied to confirm it works well. On this site it is obvious it helps a lot of people struggling with alcoholism which I have, along with Bipolar Disorder. I call Gabapentin my” happy pills” that also takes away my anxiety

I’ve detoxed several times. The last one was really bad. This time My Dr. put me gabapentin 300 mg. 3 times a day and Lithium. I usually suffer withdrawals for 5-7 days. I did have anxiety for two days, but I’m on day 3, no anxiety and no cravings

What is the Side Effects of Gabapentin ?

Gabapentin is a medication primarily used to treat seizures and nerve pain. It belongs to a class of drugs known as anticonvulsants or antiepileptic drugs. Gabapentin works by affecting the neurotransmitters in the brain, specifically by modulating the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity.

Here are some common uses of gabapentin:

  1. Epilepsy: Gabapentin is approved by the FDA (Food and Drug Administration) for the treatment of partial seizures in adults and children.
  2. Nerve Pain (Neuropathic Pain): Gabapentin is frequently prescribed off-label for various types of nerve pain, including diabetic neuropathy, postherpetic neuralgia (nerve pain caused by shingles), and neuropathic pain associated with conditions such as fibromyalgia.
  3. Restless Legs Syndrome (RLS): Gabapentin may be used off-label to alleviate symptoms of restless legs syndrome, a neurological disorder characterized by uncomfortable sensations in the legs and an irresistible urge to move them.
  4. Anxiety Disorders: In some cases, gabapentin may be prescribed off-label to manage anxiety disorders, particularly in individuals who experience anxiety as a component of their neurological conditions.

Gabapentin is usually taken orally, and the dosage depends on the condition being treated, the patient’s age, kidney function, and other factors. It is available in various formulations, including capsules, tablets, and an oral solution.

While gabapentin is generally considered safe and well-tolerated, it can cause side effects such as dizziness, drowsiness, fatigue, and coordination problems. In some cases, it may also lead to more serious side effects such as suicidal thoughts, allergic reactions, or changes in mood or behavior.

It’s essential for patients to take gabapentin exactly as prescribed by their healthcare provider and to report any unusual or concerning symptoms. As with any medication, it’s important to discuss the risks and benefits with a healthcare professional before starting gabapentin therapy.

What Side Effects May I Notice from Gabapentin?

Side effects that you should report to your prescriber or health care professional as soon as possible:

    • difficulty breathing or tightening of the throat
    • swelling of lips or tongue
    • rash
    • worsening of mood, thoughts or actions of suicide or dying
    • fever
    • hyperactivity
    • hostile or aggressive behavior
    • mood changes or changes in behavior
    • difficulty concentrating

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

    • constipation
    • difficulty walking or controlling muscle movements
    • dizziness, drowsiness
    • dry mouth
    • back pain, joint aches and pains
    • indigestion, gas or heartburn
    • loss of appetite
    • nausea
    • pain, burning or tingling in the hands or feet
    • restlessness
    • sexual difficulty (impotence)
    • skin itching
    • slurred speech
    • sore gums
    • tremor
    • weight gain

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Clumsiness or unsteadiness
  2. continuous, uncontrolled, back-and-forth, or rolling eye movements

More common in children

  1. Aggressive behavior or other behavior problems
  2. anxiety
  3. concentration problems and change in school performance
  4. crying
  5. depression
  6. false sense of well-being
  7. hyperactivity or increase in body movements
  8. rapidly changing moods
  9. reacting too quickly, too emotional, or overreacting
  10. restlessness
  11. suspiciousness or distrust

Less common

  1. Black, tarry stools
  2. chest pain
  3. chills
  4. cough
  5. depression, irritability, or other mood or mental changes
  6. fever
  7. loss of memory
  8. pain or swelling in the arms or legs
  9. painful or difficult urination
  10. shortness of breath
  11. sore throat
  12. sores, ulcers, or white spots on the lips or in the mouth
  13. swollen glands
  14. unusual bleeding or bruising
  15. unusual tiredness or weakness

Incidence not known

  1. Abdominal or stomach pain
  2. blistering, peeling, or loosening of the skin
  3. clay-colored stools
  4. coma
  5. confusion
  6. convulsions
  7. dark urine
  8. decreased urine output
  9. diarrhea
  10. dizziness
  11. fast or irregular heartbeat
  12. headache
  13. increased thirst
  14. itching or skin rash
  15. joint pain
  16. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  17. loss of appetite
  18. muscle ache or pain
  19. nausea
  20. red skin lesions, often with a purple center
  21. red, irritated eyes
  22. unpleasant breath odor
  23. vomiting of blood
  24. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Blurred vision
  2. cold or flu-like symptoms
  3. delusions
  4. dementia
  5. hoarseness
  6. lack or loss of strength
  7. lower back or side pain
  8. swelling of the hands, feet, or lower legs
  9. trembling or shaking

Less common or rare

  1. Accidental injury
  2. appetite increased
  3. back pain
  4. bloated or full feeling
  5. body aches or pain
  6. burning, dry, or itching eyes
  7. change in vision
  8. change in walking and balance
  9. clumsiness or unsteadiness
  10. congestion
  11. constipation
  12. cough producing mucus
  13. decrease in sexual desire or ability
  14. difficulty with breathing
  15. dryness of the mouth or throat
  16. earache
  17. excess air or gas in the stomach or intestines
  18. excessive tearing
  19. eye discharge
  20. feeling faint, dizzy, or lightheadedness
  21. feeling of warmth or heat
  22. flushed, dry skin
  23. flushing or redness of the skin, especially on the face and neck
  24. frequent urination
  25. fruit-like breath odor
  26. impaired vision
  27. incoordination
  28. increased hunger
  29. increased sensitivity to pain
  30. increased sensitivity to touch
  31. increased thirst
  32. indigestion
  33. noise in the ears
  34. pain, redness, rash, swelling, or bleeding where the skin is rubbed off
  35. passing gas
  36. redness or swelling in the ear
  37. redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  38. runny nose
  39. sneezing
  40. sweating
  41. tender, swollen glands in the neck
  42. tightness in the chest
  43. tingling in the hands and feet
  44. trouble sleeping
  45. trouble swallowing
  46. trouble thinking
  47. twitching
  48. unexplained weight loss
  49. voice changes
  50. vomiting
  51. weakness or loss of strength
  52. weight gain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

We do not suggest you to take Fioricet or Gabapentin for a long time, you need go to your local health professional to treat your pain without prescription. We think exercising is the best way to relieve your pain. Exercising is a very good methods. Exercising can enhance your immune system and increase your muscle strength and make your nerve strong.
You can also take some nutrition from food.

We do not suggest you to take Fioricet or Gabapentin for a long time, you need go to your local health professional to treat your pain without prescription. We think exercising is the best way to relieve your pain. Exercising is a very good methods. Exercising can enhance your immune system and increase your muscle strength and make your nerve strong.

You can also take some USANA Nature nutrition from food. and make you happier by taking Celavive® Skin Care USANA Products, USANA toothepaste

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Gabapentin Tips

The Neurontin brand of gabapentin can be taken with or without food.

If you’ve been prescribed gabapentin, here are some tips to consider for safe and effective usage:

  1. Follow Your Doctor’s Instructions: Always take gabapentin exactly as prescribed by your doctor. Do not alter the dosage or frequency without consulting them first.
  2. Take with or without Food: Gabapentin can be taken with or without food. However, consistency in how you take it (with food or without) is recommended to maintain consistent blood levels.
  3. Swallow Whole: Swallow the gabapentin capsule or tablet whole with a full glass of water. Do not crush, chew, or break the tablets, as this can alter the way the medication is released into your system.
  4. Stick to the Schedule: Try to take gabapentin at the same times each day to help you remember and maintain consistent levels of the medication in your bloodstream.
  5. Do Not Stop Abruptly: If you need to discontinue gabapentin, consult your doctor for guidance on how to gradually reduce your dosage over time. Suddenly stopping gabapentin can lead to withdrawal symptoms or a return of your original condition.
  6. Monitor Side Effects: Pay attention to any side effects you may experience while taking gabapentin and report them to your doctor. Common side effects include dizziness, drowsiness, fatigue, and coordination problems.
  7. Avoid Alcohol and CNS Depressants: Gabapentin can enhance the effects of alcohol and other central nervous system (CNS) depressants, increasing the risk of drowsiness and impairment. Avoid alcohol and discuss with your doctor any other medications or substances you’re taking.
  8. Be Cautious with Driving and Machinery: Gabapentin may cause dizziness and drowsiness, which can impair your ability to drive or operate machinery safely. Exercise caution until you know how gabapentin affects you.
  9. Stay Hydrated: Drinking plenty of water can help alleviate some potential side effects of gabapentin, such as constipation.
  10. Store Properly: Store gabapentin at room temperature away from moisture and heat. Keep it out of reach of children and pets.

If you break a 600mg or 800mg Neurontin tablet in half, be sure to take the other half at your next dose or within 28 days.

The Gralise brand of gabapentin cannot be substituted for other gabapentin products due to differing administration requirements (once daily versus three times daily for other products).

Gralise should be taken with food at the evening meal. Gralise tablets should be swallowed whole; do not cut, crush, or chew.

Horizant (gabapentin enacarbil) tablets should be swallowed whole and taken with food. For restless leg syndrome, take at roughly 5 PM in the evening. Do not cut, crush, or chew the tablet. Do not interchange Horizant with other gabapentin products.

Use a manufacturer-provided or pharmacist-provided measuring cup calibrated for liquid formulations when measuring liquid doses of gabapentin. Do not use a kitchen measuring device or teaspoon because these may be inaccurate.

For dosage schedules of three times daily do not allow more than 12 hours between doses.

Monitor for mood changes and report any evidence of new or worsening mood or depression to the prescribing doctor.

Do not take gabapentin at the same time as antacids such as Maalox or Gaviscon. Separate administration by at least two hours. Take exactly as directed by your doctor, do not increase or decrease the dose without his or her advice.

Avoid operating machinery, driving, or performing tasks that require mental alertness if gabapentin makes your drowsy or impairs your judgment.

The side effects of gabapentin, such as dizziness or drowsiness, may increase your risk of falling. Remove any fall hazards from your home if possible (such as loose rugs), and be careful when ascending or descending stairs.

Talk to your doctor if you experience any worsening of your mood or if you develop any suicidal thoughts.

Do not stop taking gabapentin without your doctor’s advice as it may precipitate a withdrawal reaction (symptoms include agitation, disorientation, confusion). When the time comes to discontinue gabapentin your doctor will tell you how to taper it off.

Seek urgent medical advice if you develop a rash, fever, difficulty breathing or facial swelling while taking gabapentin.

How Does Gabapentin Work ?

Gabapentin is a medicine that may be used for the treatment of certain seizure disorders or nerve pain.

Gabapentin is a medication primarily used to treat seizures and nerve pain. It belongs to a class of drugs known as anticonvulsants or antiepileptic drugs. Gabapentin works by affecting the neurotransmitters in the brain, specifically by modulating the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits brain activity.

Here are some common uses of gabapentin:

  1. Epilepsy: Gabapentin is approved by the FDA (Food and Drug Administration) for the treatment of partial seizures in adults and children.
  2. Nerve Pain (Neuropathic Pain): Gabapentin is frequently prescribed off-label for various types of nerve pain, including diabetic neuropathy, postherpetic neuralgia (nerve pain caused by shingles), and neuropathic pain associated with conditions such as fibromyalgia.
  3. Restless Legs Syndrome (RLS): Gabapentin may be used off-label to alleviate symptoms of restless legs syndrome, a neurological disorder characterized by uncomfortable sensations in the legs and an irresistible urge to move them.
  4. Anxiety Disorders: In some cases, gabapentin may be prescribed off-label to manage anxiety disorders, particularly in individuals who experience anxiety as a component of their neurological conditions.

Gabapentin works by affecting the activity of certain neurotransmitters in the brain, particularly gamma-aminobutyric acid (GABA). GABA is an inhibitory neurotransmitter, meaning it reduces the activity of neurons in the brain and central nervous system, leading to a calming or inhibitory effect.

Here’s how gabapentin works:

  1. Modulation of Calcium Channels: Gabapentin binds to a specific type of calcium channel known as the α2δ subunit of voltage-gated calcium channels in the central nervous system. By binding to these channels, gabapentin reduces the influx of calcium ions into neurons. This modulation of calcium channels leads to a decrease in the release of excitatory neurotransmitters such as glutamate.
  2. Increased GABA Levels: Gabapentin indirectly increases the concentration of GABA in the brain. Although it does not directly affect GABA receptors, gabapentin’s modulation of calcium channels leads to an increase in GABA synthesis and release from neurons. This increase in GABA levels enhances inhibitory signaling in the brain, which can help reduce neuronal excitability and dampen the transmission of pain signals.
  3. Neuropathic Pain Relief: Gabapentin’s ability to modulate calcium channels and increase GABA levels is thought to be responsible for its effectiveness in relieving neuropathic pain. Neuropathic pain results from damage or dysfunction of the nerves and is characterized by abnormal signaling in the nervous system. By reducing neuronal excitability and dampening abnormal signaling, gabapentin can help alleviate neuropathic pain.
  4. Antiepileptic Effects: Gabapentin’s modulation of calcium channels and enhancement of GABAergic activity contribute to its antiepileptic effects. By reducing neuronal excitability and inhibiting the spread of abnormal electrical activity in the brain, gabapentin helps prevent seizures in individuals with epilepsy.

Experts aren’t sure exactly how gabapentin works, but research has shown that gabapentin binds strongly to a specific site (called the alpha2-delta site) on voltage-gated calcium channels. This action is thought to be the mechanism for its nerve-pain relieving and anti-seizure properties.

Gabapentin enacarbil (brand name Horizant) is a prodrug of gabapentin which has been designed to overcome the limitations of gabapentin, such as poor absorption and a short duration of action. Gabapentin enacarbil is effective for restless legs syndrome (RLS) and postherpetic neuralgia (nerve pain that occurs following Shingles).

Gabapentin belongs to the group of medicines known as anticonvulsants.

 

Gabapentin Warnings

You can buy generic Neurontin (Gabapentin) from any online source that is a reputed internet medicine store. This will help you get the most deserved discounts and it will surely help you save some pennies.

Even though you buy this medication from apt sources and you have surety of quality, some side effects with this medication are always there.

This happens with almost all the medications that are available in the market. Some people face less number of side effects while some patients have more side effects with some medications. Thus like every other medication even generic Neurontin comes with this package.

gabapentin can cause problems, especially if it is not used as directed or if certain precautions are not followed. Some potential issues associated with gabapentin use include:

  1. Side Effects: Common side effects of gabapentin include dizziness, drowsiness, fatigue, coordination problems, blurred vision, and weight gain. These side effects are usually mild to moderate and often improve over time. However, some individuals may experience more severe or persistent side effects.
  2. Dependency and Withdrawal: Although gabapentin is not considered a controlled substance, there have been reports of dependence and withdrawal symptoms, especially in individuals who misuse or abuse the medication. Withdrawal symptoms may include anxiety, insomnia, nausea, sweating, and flu-like symptoms.
  3. Interaction with Other Medications: Gabapentin can interact with certain medications, including opioids, benzodiazepines, and other central nervous system depressants. Combining gabapentin with these substances can increase the risk of sedation, respiratory depression, and overdose.
  4. Suicidal Thoughts and Behavior: Gabapentin and other antiepileptic drugs have been associated with an increased risk of suicidal thoughts and behavior. Patients taking gabapentin should be closely monitored for changes in mood, behavior, or suicidal ideation, especially when starting or changing the dose of the medication.
  5. Allergic Reactions: Some individuals may experience allergic reactions to gabapentin, which can manifest as rash, itching, swelling, or difficulty breathing. In rare cases, severe allergic reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur, which require immediate medical attention.
  6. Renal Impairment: Gabapentin is primarily eliminated from the body through the kidneys. Therefore, individuals with impaired kidney function may require dose adjustments or closer monitoring to prevent accumulation of the medication and potential toxicity.
  7. Cognitive Impairment: Some individuals may experience cognitive impairment, memory problems, or confusion while taking gabapentin, especially at higher doses or in combination with other medications.

Before taking this medicine

You should not use gabapentin if you are allergic to it.

To make sure this medicine is safe for you, tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);
  • diabetes;
  • depression, a mood disorder, or suicidal thoughts or actions;
  • a seizure (unless you take gabapentin to treat seizures);
  • liver disease;
  • heart disease; or
  • are taking an anti-depressant or sedating medication; or
  • (for patients with RLS) if you are a day sleeper or work a night shift.

Some people have thoughts about suicide while taking this medicine. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Seizure control is very important during pregnancy, and having a seizure could harm both mother and baby. Do not start or stop taking gabapentin for seizures without your doctor’s advice, and tell your doctor right away if you become pregnant.

Gabapentin Pregnancy Warnings

Animal studies have revealed evidence of fetotoxicity involving delayed ossification in several bones of the skull, vertebrae, forelimbs, and hindlimbs. Hydroureter and hydronephrosis have also been reported in animal studies. There are no controlled data in human pregnancy.

To provide information regarding the effects of in utero exposure to this drug, physicians are advised to recommend that pregnant patients enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry. This can be done by calling the toll free number 1-888-233-2334, and must be done by patients themselves. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/.

AU TGA pregnancy category B1: Drugs which have been taken by only a limited number of pregnant women and women of childbearing age, without an increase in the frequency of malformation or other direct or indirect harmful effects on the human fetus having been observed. Studies in animals have not shown evidence of an increased occurrence of fetal damage.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

This drug should be used during pregnancy only if the benefit outweighs the risk.

AU TGA pregnancy category: B1
US FDA pregnancy category: C

Comments:
-Women on antiepileptic drugs (AEDs) should receive prepregnancy counseling with regard to the risk of fetal abnormalities.
-AEDs should be continued during pregnancy and monotherapy should be used if possible at the lowest effective dose as the risk of abnormality is greater in women taking combined medication.
-Folic acid supplementation (5 mg) should be started 4 weeks prior to and continued for 12 weeks after conception.
-Specialized prenatal diagnosis including detailed mid-trimester ultrasound should be offered.
-The risk of having a child with a congenital defect as a result of antiepileptic medication is far outweighed by the dangers to the mother and fetus of uncontrolled epilepsy.

Gabapentin Breastfeeding Warnings

Benefit should outweigh risk.

Excreted into human milk: Yes

Comments:
-The effects in the nursing infant are unknown.
-Limited information indicates that maternal doses up to 2.1 g daily produce relatively low levels in infant serum.
-Breastfed infants should be monitored for drowsiness, adequate weight gain, and developmental milestones, especially in younger, exclusively breastfed infants and when using combinations of anticonvulsant or psychotropic drugs.

 

Can Gabapentin Cause Problems?

Yes, gabapentin can cause problems, especially if it is not used as directed or if certain precautions are not followed.

Some potential issues associated with gabapentin use include:

  1. Side Effects: Common side effects of gabapentin include dizziness, drowsiness, fatigue, coordination problems, blurred vision, and weight gain. These side effects are usually mild to moderate and often improve over time. However, some individuals may experience more severe or persistent side effects.
  2. Dependency and Withdrawal: Although gabapentin is not considered a controlled substance, there have been reports of dependence and withdrawal symptoms, especially in individuals who misuse or abuse the medication. Withdrawal symptoms may include anxiety, insomnia, nausea, sweating, and flu-like symptoms.
  3. Interaction with Other Medications: Gabapentin can interact with certain medications, including opioids, benzodiazepines, and other central nervous system depressants. Combining gabapentin with these substances can increase the risk of sedation, respiratory depression, and overdose.
  4. Suicidal Thoughts and Behavior: Gabapentin and other antiepileptic drugs have been associated with an increased risk of suicidal thoughts and behavior. Patients taking gabapentin should be closely monitored for changes in mood, behavior, or suicidal ideation, especially when starting or changing the dose of the medication.
  5. Allergic Reactions: Some individuals may experience allergic reactions to gabapentin, which can manifest as rash, itching, swelling, or difficulty breathing. In rare cases, severe allergic reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis may occur, which require immediate medical attention.
  6. Renal Impairment: Gabapentin is primarily eliminated from the body through the kidneys. Therefore, individuals with impaired kidney function may require dose adjustments or closer monitoring to prevent accumulation of the medication and potential toxicity.
  7. Cognitive Impairment: Some individuals may experience cognitive impairment, memory problems, or confusion while taking gabapentin, especially at higher doses or in combination with other medications.

Side Effects of Gabapentin

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them.

The table below contains some of the most common ones associated with gabapentin.

You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common gabapentin side-effects
 What can I do if I experience this?
Feeling sleepy, tired, unsteady or dizzy; blurred vision and other eyesight problems Do not drive or use tools or machines
Headache Ask your pharmacist to recommend a suitable painkiller
Feeling or being sick, indigestion, stomach ache Stick to simple foods – avoid rich or spicy meals
Diarrhoea Drink plenty of water to replace the lost fluids
Constipation Try to eat a well-balanced diet and drink several glasses of water each day
Dry mouth Try chewing sugar-free gum or sucking sugar-free sweets
Infections, flu-like symptoms, increased appetite, flushing,
increased blood pressure, changes in weight, changes in emotions or mood, fits, movement difficulties, feeling shaky, difficulties sleeping, breathing difficulties, cough, gum changes, bruises, muscle or joint pains, impotence, and swollen feet or ankles		 If any of these become troublesome, speak with your doctor for advice

Important: gabapentin has been associated with a number of unwanted effects which affect the blood, pancreas and liver.

Although these occur less commonly than the side-effects listed above, you must let your doctor know straightaway if you notice any of the following as they could be serious:

    • Persistent stomach pain with sickness (these could be symptoms of an inflamed pancreas).
    • A skin rash, or any swelling of your mouth or face (these could be symptoms of an allergic reaction).
    • Any yellowing of your skin or of the whites of your eyes (these could be symptoms of jaundice).
    • Any unusual bruising or bleeding (these could be symptoms of a blood disorder).

If you experience any other symptoms which you think may be due to the medicine, speak with your doctor or pharmacist for further advice.

How Many Diseases can Gabapentin Used for ?

Gabapentin, primarily prescribed for controlling seizures and managing nerve pain caused by shingles, has several off-label uses. Some of these include:

  1. Chronic Pain Management: Gabapentin is often prescribed off-label for chronic pain conditions such as diabetic neuropathy, fibromyalgia, and chronic lower back pain.
  2. Anxiety Disorders: Some clinicians prescribe gabapentin off-label to treat certain anxiety disorders, including generalized anxiety disorder (GAD), social anxiety disorder (SAD), and panic disorder.
  3. Bipolar Disorder: In some cases, gabapentin may be used off-label as an adjunctive treatment for bipolar disorder, particularly for managing certain symptoms like anxiety or mood stabilization.
  4. Insomnia: Gabapentin can be used off-label to aid in sleep and treat insomnia, especially in individuals who experience sleep disturbances due to chronic pain or anxiety.
  5. Alcohol Withdrawal: It’s been found to be effective in managing symptoms of alcohol withdrawal, such as anxiety, agitation, and tremors, although its use in this context is not as common as other medications like benzodiazepines.
  6. Migraine Prevention: Some studies suggest that gabapentin may be effective in preventing migraines, particularly in individuals who haven’t responded well to other medications or who experience side effects from standard migraine treatments.
  7. Restless Legs Syndrome (RLS): Gabapentin may be used off-label to alleviate symptoms of RLS, such as uncomfortable sensations in the legs and an uncontrollable urge to move them, especially if other treatments haven’t provided relief.
  8. Neuropathic Itch: There’s emerging evidence to suggest that gabapentin may be effective in treating neuropathic itch, a condition characterized by chronic itching due to nerve damage.

It’s important to note that using gabapentin off-label should be done under the guidance of a healthcare professional, as they can assess the risks and benefits based on individual circumstances and medical history. Off-label use means the medication hasn’t been specifically approved by regulatory agencies for these conditions, so caution should be exercised and informed consent obtained from the patient.

There are a lot of off label usage of Gabapentin in drugs.com reviews.

Gabapentin Usage

Gabapentin Can be used for a lot of Nerve Pain related health conditions including Cough, Hot Flashes, Alcohol Withdrawal, Anxiety 161 reviews, Bipolar Disorder, Trigeminal Neuralgia, Postherpetic Neuralgia, Migraine, Insomnia， Occipital Neuralgia， Peripheral Neuropathy，Vulvodynia, Benign Essential Tremor, Epilepsy, Fibromyalgia, Pain Relief, Diabetic Peripheral Neuropathy , Neuropathic Pain，Reflex Sympathetic Dystrophy Syndrome，Periodic Limb Movement Disorder， Spondylolisthesis， Burning Mouth Syndrome，Pudendal Neuralgia， Small Fiber Neuropathy.

Use only the brand and form of gabapentin that your doctor has prescribed. Check your medicine each time you get a refill at the pharmacy, to make sure you have received the correct form of this medication. Do not stop taking Gabapentin unless your doctor tells you to. If your treatment is stopped it should be done gradually over a minimum of 1 week. If you stop taking gabapentin suddenly or before your doctor tells you, there is an increased risk of seizures.